Title: Frontier Bioscience Studies in Quantitative Biology Center.
Schedule
February 4th
10:30-12:00 Makoto Taiji
13:00-14:30 Chikara Furusawa
14:40-16:10 Yasushi Okada
February 5th
10:30-12:00 Yuichi Taniguchi
13:00-14:30 Kenta Sumiyama
14:40-16:10 Yo Tanaka
Title and abstracts
Taiji
Molecular Dynamics Simulations with a special-purpose computer
Molecular Dynamics (MD) simulation is one of the major computational approach for the predictions of biomolecular properties. Recently, a few special-purpose supercomputers for MD simulations have been developed to enable simulations of slow and large-scale dynamics of proteins. I will introduce the architecture of the machine and explain their importance and applications and importance.
Furusawa
Universal Biology of Evolution: Theoretical and Experimental Approaches
Biological systems change their state to evolve and adapt to changes in environmental conditions. To understand the nature of adaptive evolution, quantitative experiments and theoretical analysis are necessary. In this lecture, I will introduce a quantitative analysis of laboratory evolution experiments and theoretical analysis of such high-dimensional phenotypic/genotypic data.
Okada
Next generation bioimaging
Microscope techniques are a major driving force in biological studies. Light microscopy and related techniques are revolutionarily advancing in the past ten years. I will introduce the basic principles behind these new microscopy technologies and discuss on the current and future impacts on the biological studies.
Taniguchi
Super-resolution 3D genome structure analysis
Recent 3D genome structure analysis techniques have emerged by utilizing next generation sequencing. Our laboratory is currently pursuing the world’s highest resolution with these techniques, by integrating biochemistry methods and molecular dynamics simulation. I will introduce the background and principle of the techniques, and argue their potential for future application.
Sumiyama
Next generation mammalian genetics
Organism-level reverse genetics in mammal is necessary to identify and analyze various biological phenotypes. I will introduce recent advances in reverse genetics in mammals by using genome editing technology, including genome modification of zygote or ES cell by CRISPR/Cas9 technology and mammalian genetics without crossing, and discuss current problems and future perspective.
Tanaka
Next generation biological experiments using microdevices
Microdevice techniques are becoming a major driving force in biological studies. Microfabrication and related techniques are revolutionarily advancing in the past ten years. I will introduce the basic principles behind these new microdevice technologies and discuss on the current and future impacts on the biological studies as applications.
