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阪大生命機能集中講義2018

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集中講義タイトル:QBiCで展開する先端生命科学研究
Title: Frontier Bioscience Studies in Quantitative Biology Center.

世話教員:岡田康志(招へい教授)
担当教員:岡田康志、泰地真弘人、古澤力、谷口雄一、隅山健太、田中陽

日程/時間割 Schedule
February 4th
10:30-12:00 泰地真弘人Makoto Taiji
13:00-14:30 古澤力Chikara Furusawa
14:40-16:10 岡田康志 Yasushi Okada
February 5th
10:30-12:00 谷口雄一Yuichi Taniguchi
13:00-14:30 隅山健太Kenta Sumiyama
14:40-16:10 田中陽 Yo Tanaka

各講義のタイトルと概要
泰地 Taiji
Molecular Dynamics Simulations with a special-purpose computer

Molecular Dynamics (MD) simulation is one of the major computational approach for the predictions of biomolecular properties. Recently, a few special-purpose supercomputers for MD simulations have been developed to enable simulations of slow and large-scale dynamics of proteins. I will introduce the architecture of the machine and explain their importance and applications and importance.

古澤 Furusawa
Universal Biology of Evolution: Theoretical and Experimental Approaches

Biological systems change their state to evolve and adapt to changes in environmental conditions. To understand the nature of adaptive evolution, quantitative experiments and theoretical analysis are necessary. In this lecture, I will introduce a quantitative analysis of laboratory evolution experiments and theoretical analysis of such high-dimensional phenotypic/genotypic data.

岡田 Okada
Next generation bioimaging

Microscope techniques are a major driving force in biological studies. Light microscopy and related techniques are revolutionarily advancing in the past ten years. I will introduce the basic principles behind these new microscopy technologies and discuss on the current and future impacts on the biological studies.

谷口 Taniguchi
Super-resolution 3D genome structure analysis

Recent 3D genome structure analysis techniques have emerged by utilizing next generation sequencing. Our laboratory is currently pursuing the world’s highest resolution with these techniques, by integrating biochemistry methods and molecular dynamics simulation. I will introduce the background and principle of the techniques, and argue their potential for future application.

隅山Sumiyama
Next generation mammalian genetics

Organism-level reverse genetics in mammal is necessary to identify and analyze various biological phenotypes. I will introduce recent advances in reverse genetics in mammals by using genome editing technology, including genome modification of zygote or ES cell by CRISPR/Cas9 technology and mammalian genetics without crossing, and discuss current problems and future perspective.

田中Tanaka
Next generation biological experiments using microdevices

Microdevice techniques are becoming a major driving force in biological studies. Microfabrication and related techniques are revolutionarily advancing in the past ten years. I will introduce the basic principles behind these new microdevice technologies and discuss on the current and future impacts on the biological studies as applications.

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